Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[62] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...

Losmapimod 💬

[2] 113, 222 💬

2

[62] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...

Neflamapimod 💬

[1] 8 💬

3

[51] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 ...

[40] 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, ...

Disease ID	Name
2	Amyotrophic lateral sclerosis
13	Multiple sclerosis/Neuromyelitis optica
15	Inclusion body myositis
17	Multiple system atrophy
19	Lysosomal storage disease
34	Neurofibromatosis
35	Pemphigus
36	Epidermolysis bullosa
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
51	Scleroderma
53	Sjogren syndrome
60	Aplastic anemia
61	Autoimmune hemolytic anemia
62	Paroxysmal nocturnal hemoglobinuria
63	Idiopathic thrombocytopenic purpura
65	Primary immunodeficiency
66	IgA nephropathy
67	Polycystic kidney disease
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
89	Lymphangioleiomyomatosis
96	Crohn disease
98	Eosinophilic gastrointestinal disease
137	Focal cortical dysplasia
157	Sturge-Weber syndrome
158	Tuberous sclerosis
192	Cockayne syndrome
193	Prader-Willi syndrome
222	Primary nephrotic syndrome
256	Muscle glycogenosis
277	Lymphangiomatosis
278	Huge lymphatic malformation with cervicofacial lesion
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion
280	Huge arteriovenous malformation with cervicofacial or limb lesion
281	Klippel-Trenaunay-Weber syndrome
283	Acquired pure red cell aplasia
300	IgG4-related disease
331	Idiopathic multicentric castleman disease

4

[51] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 ...

Everolimus 💬

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis
67	Polycystic kidney disease
89	Lymphangioleiomyomatosis
96	Crohn disease
137	Focal cortical dysplasia
157	Sturge-Weber syndrome
158	Tuberous sclerosis
228	Bronchiolitis obliterans
277	Lymphangiomatosis

5

[51] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 ...

Temsirolimus 💬

[1] 13 💬

6

[5] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signal ...

Mecasermin 💬

[6] 65, 78, 96, 168, 265, 299 💬

7

[5] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signal ...

Pegvisomant 💬

[2] 78, 265 💬

8

[5] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signal ...

Somavaratan 💬

[1] 78 💬

9

[5] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signal ...

Somapacitan 💬

[2] 78, 195 💬

10

[5] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signal ...

Lonapegsomatropin 💬

Lonapegsomatropin

[1] 78 💬

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