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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
CDK4
💬
1. CDK4
×
Name
Full Name
CDK4
cyclin dependent kinase 4
[28]
Endocrine resistance
Endocrine resistance
,
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular senescence
,
Tight junction
,
T cell receptor signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Hepatitis C
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
Glioma
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Small cell lung cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
[28]
Endocrine resistance
,
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular s
...
Abemaciclib
Abemaciclib
💬
1. CDK4
×
Name
Other Names
Abemaciclib
Abemaciclib (JAN/USAN)
Verzenio (TN)
Abemaciclib
[1]
34
34
💬
1. CDK4
×
Disease ID
Name
34
Neurofibromatosis
2
CDK6
💬
2. CDK6
×
Name
Full Name
CDK6
cyclin dependent kinase 6
[23]
Cell cycle
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular senescence
,
Cushing syndrome
,
Hepatitis C
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Viral carcinogenesis
,
MicroRNAs in cancer
,
Pancreatic cancer
,
Glioma
,
Melanoma
,
Chronic myeloid leukemia
,
Small cell lung cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
[23]
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular senescence
,
Cushing syn
...
Abemaciclib
Abemaciclib
💬
2. CDK6
×
Name
Other Names
Abemaciclib
Abemaciclib (JAN/USAN)
Verzenio (TN)
Abemaciclib
[1]
34
34
💬
2. CDK6
×
Disease ID
Name
34
Neurofibromatosis
3
CCR4
💬
3. CCR4
×
Name
Full Name
CCR4
C-C motif chemokine receptor 4
[5]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
Chemokine signaling pathway
,
Kaposi sarcoma-associated herpesvirus infection
,
Viral carcinogenesis
[5]
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine rec
...
Mogamulizumab
Mogamulizumab
💬
3. CCR4
×
Name
Other Names
Mogamulizumab
Mogamulizumab (USAN)
Mogamulizumab (genetical recombination) (JAN)
Mogamulizumab-kpkc
Poteligeo (TN)
Mogamulizumab
[1]
26
26
💬
3. CCR4
×
Disease ID
Name
26
HTLV-1-associated myelopathy
4
CCR5
💬
4. CCR5
×
Name
Full Name
CCR5
C-C motif chemokine receptor 5
[11]
Viral life cycle - HIV-1
Viral life cycle - HIV-1
,
Virion - Human immunodeficiency virus
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
Chemokine signaling pathway
,
Endocytosis
,
Toxoplasmosis
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Human immunodeficiency virus 1 infection
,
Viral carcinogenesis
[11]
Viral life cycle - HIV-1
,
Virion - Human immunodeficiency virus
,
Cytokine-cytokine receptor int
...
Maraviroc
Maraviroc
💬
4. CCR5
×
Name
Other Names
Maraviroc
Maraviroc (JAN/INN)
Selzentry (TN)
Maraviroc
[2]
46
46
,
84
💬
4. CCR5
×
Disease ID
Name
46
Malignant rheumatoid arthritis
84
Sarcoidosis
5
CCR5
💬
5. CCR5
×
Name
Full Name
CCR5
C-C motif chemokine receptor 5
[11]
Viral life cycle - HIV-1
Viral life cycle - HIV-1
,
Virion - Human immunodeficiency virus
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
Chemokine signaling pathway
,
Endocytosis
,
Toxoplasmosis
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Human immunodeficiency virus 1 infection
,
Viral carcinogenesis
[11]
Viral life cycle - HIV-1
,
Virion - Human immunodeficiency virus
,
Cytokine-cytokine receptor int
...
Cenicriviroc
Cenicriviroc
💬
5. CCR5
×
Name
Other Names
Cenicriviroc
Cenicriviroc (USAN/INN)
Cenicriviroc
[1]
94
94
💬
5. CCR5
×
Disease ID
Name
94
Primary sclerosing cholangitis
6
MAPK14
💬
6. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
6. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
Losmapimod
[2]
113
113
,
222
💬
6. MAPK14
×
Disease ID
Name
113
Muscular dystrophy
222
Primary nephrotic syndrome
7
MAPK14
💬
7. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
7. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
Neflamapimod
[1]
8
8
💬
7. MAPK14
×
Disease ID
Name
8
Huntington disease
8
CSF2
💬
8. CSF2
×
Name
Full Name
CSF2
colony stimulating factor 2
[16]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Shigellosis
,
Amoebiasis
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Coronavirus disease - COVID-19
,
Transcriptional misregulation in cancer
,
Acute myeloid leukemia
,
Rheumatoid arthritis
[16]
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
, ...
Otilimab
Otilimab
💬
8. CSF2
×
Name
Other Names
Otilimab
Otilimab (USAN)
Otilimab (genetical recombination) (JAN)
Otilimab
[1]
46
46
💬
8. CSF2
×
Disease ID
Name
46
Malignant rheumatoid arthritis
9
MTOR
💬
9. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
[51]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
[51]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Sirolimus
Sirolimus
💬
9. MTOR
×
Name
Other Names
Sirolimus
Sirolimus (JAN/USAN/INN)
Rapamune (TN)
Rapamycin (TN)
FYARRO
HYFTOR
Sirolimus
[40]
2
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
,
98
,
137
,
157
,
158
,
192
,
193
,
222
,
256
,
277
,
278
,
279
,
280
,
281
,
283
,
300
,
331
💬
[40]
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
, ...
9. MTOR
×
Disease ID
Name
2
Amyotrophic lateral sclerosis
13
Multiple sclerosis/Neuromyelitis optica
15
Inclusion body myositis
17
Multiple system atrophy
19
Lysosomal storage disease
34
Neurofibromatosis
35
Pemphigus
36
Epidermolysis bullosa
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
51
Scleroderma
53
Sjogren syndrome
60
Aplastic anemia
61
Autoimmune hemolytic anemia
62
Paroxysmal nocturnal hemoglobinuria
63
Idiopathic thrombocytopenic purpura
65
Primary immunodeficiency
66
IgA nephropathy
67
Polycystic kidney disease
84
Sarcoidosis
85
Idiopathic interstitial pneumonia
86
Pulmonary arterial hypertension
89
Lymphangioleiomyomatosis
96
Crohn disease
98
Eosinophilic gastrointestinal disease
137
Focal cortical dysplasia
157
Sturge-Weber syndrome
158
Tuberous sclerosis
192
Cockayne syndrome
193
Prader-Willi syndrome
222
Primary nephrotic syndrome
256
Muscle glycogenosis
277
Lymphangiomatosis
278
Huge lymphatic malformation with cervicofacial lesion
279
Huge venous malformation with cervical, oral and pharyngeal diffuse lesion
280
Huge arteriovenous malformation with cervicofacial or limb lesion
281
Klippel-Trenaunay-Weber syndrome
283
Acquired pure red cell aplasia
300
IgG4-related disease
331
Idiopathic multicentric castleman disease
10
MTOR
💬
10. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
[51]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
[51]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Everolimus
Everolimus
💬
10. MTOR
×
Name
Other Names
Everolimus
Everolimus (JAN/USAN/INN)
Afinitor (TN)
Votubia (TN)
Zortress (TN)
Everolimus
[9]
34
34
,
67
,
89
,
96
,
137
,
157
,
158
,
228
,
277
💬
10. MTOR
×
Disease ID
Name
34
Neurofibromatosis
67
Polycystic kidney disease
89
Lymphangioleiomyomatosis
96
Crohn disease
137
Focal cortical dysplasia
157
Sturge-Weber syndrome
158
Tuberous sclerosis
228
Bronchiolitis obliterans
277
Lymphangiomatosis