Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[28] Endocrine resistance, Cell cycle, p53 signaling pathway, PI3K-Akt signaling pathway, Cellular s ...

Abemaciclib 💬

[1] 34 💬

2

[23] Cell cycle, p53 signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Cushing syn ...

Abemaciclib 💬

[1] 34 💬

3

[4] Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...

Zoledronic acid 💬

Zoledronic acid

[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬

Disease ID	Name
5	Progressive supranuclear palsy
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
17	Multiple system atrophy
46	Malignant rheumatoid arthritis
65	Primary immunodeficiency
93	Primary biliary cholangitis
95	Autoimmune hepatitis
96	Crohn disease
270	Chronic recurrent multifocal osteomyelitis
274	Osteogenesis Imperfecta
299	Cystic fibrosis
333	Hutchinson-Gilford syndrome

4

[4] Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...

Alendronic acid 💬

Alendronic acid

[7] 19, 41, 46, 50, 271, 274, 299 💬

5

[4] Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...

Pamidronic acid 💬

Pamidronic acid

[3] 270, 271, 274 💬

6

[4] Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...

Risedronic acid 💬

Risedronic acid

[9] 46, 50, 66, 93, 95, 96, 107, 113, 274 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
50	Dermatomyositis
66	IgA nephropathy
93	Primary biliary cholangitis
95	Autoimmune hepatitis
96	Crohn disease
107	Juvenile idiopathic arthritis
113	Muscular dystrophy
274	Osteogenesis Imperfecta

7

[4] Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...

Zoledronic acid 💬

Zoledronic acid

[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬

Disease ID	Name
5	Progressive supranuclear palsy
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
17	Multiple system atrophy
46	Malignant rheumatoid arthritis
65	Primary immunodeficiency
93	Primary biliary cholangitis
95	Autoimmune hepatitis
96	Crohn disease
270	Chronic recurrent multifocal osteomyelitis
274	Osteogenesis Imperfecta
299	Cystic fibrosis
333	Hutchinson-Gilford syndrome

8

[25] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Toll-like rece ...

Rontalizumab 💬

[1] 49 💬

9

[25] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Toll-like rece ...

Sifalimumab 💬

[1] 49 💬

10

[25] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Toll-like rece ...

Rontalizumab 💬

[1] 49 💬

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