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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
MAPK14
💬
1. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
1. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
Losmapimod
[2]
113
113
,
222
💬
1. MAPK14
×
Disease ID
Name
113
Muscular dystrophy
222
Primary nephrotic syndrome
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
2. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
Neflamapimod
[1]
8
8
💬
2. MAPK14
×
Disease ID
Name
8
Huntington disease
3
CSF1R
💬
3. CSF1R
×
Name
Full Name
CSF1R
colony stimulating factor 1 receptor
[11]
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
PI3K-Akt signaling pathway
,
Osteoclast differentiation
,
Hematopoietic cell lineage
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Acute myeloid leukemia
[11]
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Cytokine-cytokine recept
...
Sunitinib
Sunitinib
💬
3. CSF1R
×
Name
Other Names
Sunitinib
Sunitinib (INN)
Sunitinib
[2]
28
28
,
34
💬
3. CSF1R
×
Disease ID
Name
28
Systemic amyloidosis
34
Neurofibromatosis
4
CSF1R
💬
4. CSF1R
×
Name
Full Name
CSF1R
colony stimulating factor 1 receptor
[11]
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
PI3K-Akt signaling pathway
,
Osteoclast differentiation
,
Hematopoietic cell lineage
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Acute myeloid leukemia
[11]
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Cytokine-cytokine recept
...
Pexidartinib
Pexidartinib
💬
4. CSF1R
×
Name
Other Names
Pexidartinib
Pexidartinib (USAN/INN)
Pexidartinib
[1]
34
34
💬
4. CSF1R
×
Disease ID
Name
34
Neurofibromatosis
5
EGFR
💬
5. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
[48]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
[48]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Gefitinib
Gefitinib
💬
5. EGFR
×
Name
Other Names
Gefitinib
Gefitinib (JP18/USAN/INN)
Iressa (TN)
Gefitinib
[1]
75
75
💬
5. EGFR
×
Disease ID
Name
75
Cushing disease
6
EGFR
💬
6. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
[48]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
[48]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Cetuximab
Cetuximab
💬
6. EGFR
×
Name
Other Names
Cetuximab
Cetuximab (USAN/INN)
Cetuximab (genetical recombination) (JAN)
Erbitux (TN)
Cetuximab
[2]
51
51
,
86
💬
6. EGFR
×
Disease ID
Name
51
Scleroderma
86
Pulmonary arterial hypertension
7
EGFR
💬
7. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
[48]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
[48]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Erlotinib
Erlotinib
💬
7. EGFR
×
Name
Other Names
Erlotinib
Erlotinib (INN)
Erlotinib
[1]
94
94
💬
7. EGFR
×
Disease ID
Name
94
Primary sclerosing cholangitis
8
EGFR
💬
8. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
[48]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
[48]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Lapatinib
Lapatinib
💬
8. EGFR
×
Name
Other Names
Lapatinib
Lapatinib (INN)
Lapatinib
[3]
34
34
,
74
,
75
💬
8. EGFR
×
Disease ID
Name
34
Neurofibromatosis
74
Prolactin secreting pituitary adenoma
75
Cushing disease
9
EGFR
💬
9. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
[48]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
[48]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Neratinib
Neratinib
💬
9. EGFR
×
Name
Other Names
Neratinib
Neratinib (USAN/INN)
Neratinib
[1]
34
34
💬
9. EGFR
×
Disease ID
Name
34
Neurofibromatosis
10
EGFR
💬
10. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
[48]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
[48]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Icotinib
Icotinib
💬
10. EGFR
×
Name
Other Names
Icotinib
Icotinib
Icotinib
[1]
34
34
💬
10. EGFR
×
Disease ID
Name
34
Neurofibromatosis